Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania

@article{Valvassori2014IntracerebralAO,
  title={Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania},
  author={Samira S Valvassori and Camila Orlandi Arent and Amanda Valnier Steckert and Roger Bitencourt Varela and Luciano Kurtz Jornada and Paula T. Tonin and Josiane Budni and Edemilson Mariot and Fl{\'a}vio Kapczinski and Jo{\~a}o Quevedo},
  journal={Molecular Neurobiology},
  year={2014},
  volume={52},
  pages={353-362}
}
Several studies have suggested that alterations in brain-derived neurotrophic factor (BDNF) and increased oxidative stress have a central role in bipolar disorder (BD). Intracerebroventricular (ICV) injection of ouabain (OUA) in rats alters oxidative stress parameters and decreases BDNF levels in the brain. In this context, the present study aims to investigate the effects of BDNF ICV administration on BDNF levels and oxidative stress parameters in brains of rats submitted to animal model of… CONTINUE READING
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