Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses.

Abstract

The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.

4 Figures and Tables

Statistics

050100150'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

161 Citations

Semantic Scholar estimates that this publication has 161 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Dekker2003IntracellularlyES, title={Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses.}, author={S. T. Dekker and Wendy Toussaint and George N Panayotou and Ton de Wit and P. C. de Visser and Frank G. Grosveld and Dubravka Drabek}, journal={Journal of virology}, year={2003}, volume={77 22}, pages={12132-9} }