Intracellular transport of inositol-containing sphingolipids in the yeast, Saccharomyces cerevisiae.

@article{Hechtberger1995IntracellularTO,
  title={Intracellular transport of inositol-containing sphingolipids in the yeast, Saccharomyces cerevisiae.},
  author={Petra Hechtberger and Guenther Daum},
  journal={FEBS letters},
  year={1995},
  volume={367 2},
  pages={201-4}
}
Organelles of the early protein secretion pathway (ER, Golgi) are involved in biosynthesis and intracellular migration of the yeast sphingolipids, inositolphosphorylceramide (IPC), mannosylinositolphosphorylceramide (MIPC), and mannosyldiinositolphosphorylceramide (M(IP)2C). Cycloheximide and nocodazole neither block biosynthesis of sphingolipids, nor ER to Golgi transport of IPC. In contrast, treatment of yeast cells with brefeldin A, which affects integrity of the Golgi, decreases formation… CONTINUE READING

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