Intracellular transport of class II MHC molecules directed by invariant chain

@article{Lotteau1990IntracellularTO,
  title={Intracellular transport of class II MHC molecules directed by invariant chain},
  author={Vincent Lotteau and Luc Teyton and Annick P{\'e}l{\'e}raux and Tommy Nilsson and L. K. J. Karlsson and Sandra L Schmid and Vito Quaranta and Per A. Peterson},
  journal={Nature},
  year={1990},
  volume={348},
  pages={600-605}
}
Three structural motifs in the invariant chain (li) control the intracellular transport of class II major histocompatibility complex molecules. An endo-plasmic reticulum retention signal in the full-length li suggests a role for li in the α–β heterodimer assembly. Another signal motif directs a truncated li, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated li binds α–β dimers, a third signal dominates… CONTINUE READING