Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei

@article{Duszenko1988IntracellularTO,
  title={Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei},
  author={Michael Duszenko and Ivan E. Ivanov and Michael A J Ferguson and Heide Plesken and George A. M. Cross},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={106},
  pages={77 - 86}
}
Trypanosome variant surface glycoproteins (VSGs) have a novel glycan-phosphatidylinositol membrane anchor, which is cleavable by a phosphatidylinositol-specific phospholipase C. A similar structure serves to anchor some membrane proteins in mammalian cells. Using kinetic and ultrastructural approaches, we have addressed the question of whether this structure directs the protein to the cell surface by a different pathway from the classical one described in other cell types for plasma membrane… CONTINUE READING
26 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Purification and characterization of a novel glycan - phosphoinositide - specific phospholipase C from Trypanosoma brucei

  • N. M. Soliz, A. R. Saltiel
  • J . BioL Chemo
  • 1987

Structure of the variant glycoproteins and surface coat of Trypanosoma brucei

  • G. A. M. Cross
  • Phil . Trans . R . Soc . Lond . B .
  • 1987

Similar Papers

Loading similar papers…