Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei

  title={Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei},
  author={Michael Duszenko and Ivan E. Ivanov and Michael A J Ferguson and Heide Plesken and George A. M. Cross},
  journal={The Journal of Cell Biology},
  pages={77 - 86}
Trypanosome variant surface glycoproteins (VSGs) have a novel glycan-phosphatidylinositol membrane anchor, which is cleavable by a phosphatidylinositol-specific phospholipase C. A similar structure serves to anchor some membrane proteins in mammalian cells. Using kinetic and ultrastructural approaches, we have addressed the question of whether this structure directs the protein to the cell surface by a different pathway from the classical one described in other cell types for plasma membrane… CONTINUE READING
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