Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers

@article{Quinn1991IntracellularTA,
  title={Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers},
  author={D L Quinn and Lelio Orci and Mariella Ravazzola and Harvey A. Moore},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={113},
  pages={987 - 996}
}
Human proinsulin and insulin oligomerize to form dimers and hexamers. It has been suggested that the ability of prohormones to self associate and form aggregates may be responsible for the sorting process at the trans-Golgi. To examine whether insulin oligomerization is required for proper sorting into regulated storage granules, we have constructed point mutations in human insulin B chain that have been previously shown to prevent formation of insulin hexamers (Brange, J., U. Ribel, J. F… CONTINUE READING