Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain

@article{Pieters1991IntracellularTA,
  title={Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain},
  author={Jean Pieters and H. Horstmann and Oddmund Bakke and Gareth Griffiths and Joachim Lipp},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={115},
  pages={1213 - 1223}
}
The intracellular transport and location of major histocompatibility complex (MHC) class II molecules and associated invariant chain (Ii) were investigated in a human melanoma cell line. In contrast to the class II molecules, which remain stable for greater than 4 h after synthesis, the associated Ii is proteolytically processed within 2 h. During or shortly after synthesis the NH2-terminal cytoplasmic and membrane-spanning segment is in some of the Ii molecules cleaved off; during… CONTINUE READING

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