Intracellular trafficking pathways in the assembly of connexins into gap junctions.

@article{George1999IntracellularTP,
  title={Intracellular trafficking pathways in the assembly of connexins into gap junctions.},
  author={Christopher H George and Jonathan M Kendall and W. Howard Evans},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 13},
  pages={8678-85}
}
Trafficking pathways underlying the assembly of connexins into gap junctions were examined using living COS-7 cells expressing a range of connexin-aequorin (Cx-Aeq) chimeras. By measuring the chemiluminescence of the aequorin fusion partner, the translocation of oligomerized connexins from intracellular stores to the plasma membrane was shown to occur at different rates that depended on the connexin isoform. Treatment of COS-7 cells expressing Cx32-Aeq and Cx43-Aeq with brefeldin A inhibited… CONTINUE READING

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