Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease.

@article{Whittaker2016IntracellularTO,
  title={Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease.},
  author={James W. Whittaker},
  journal={Archives of biochemistry and biophysics},
  year={2016},
  volume={592},
  pages={20-6}
}
The importance of the vitamin B6-derived pyridoxal cofactor for human health has been established through more than 70 years of intensive biochemical research, revealing its fundamental roles in metabolism. B6 deficiency, resulting from nutritional limitation or impaired uptake from dietary sources, is associated with epilepsy, neuromuscular disease and neurodegeneration. Hereditary disorders of B6 processing are also known, and genetic defects in pathways involved in transport of B6 into the… CONTINUE READING