Intracellular trafficking of lysosomal proteins and lysosomes.

  title={Intracellular trafficking of lysosomal proteins and lysosomes.},
  author={Andrej Hasilik and Christian Wrocklage and Bernd Schroeder},
  journal={International journal of clinical pharmacology and therapeutics},
  volume={47 Suppl 1},
In the synthesis and trafficking of precursors of most lysosomal matrix proteins, the stages necessary for lysosomal delivery include the addition of phosphorylated mannose-rich oligosaccharides, binding of the modified proteins to receptors, their segregation from the secretory pathways and delivery to the endosomal pathway. Targeting of both internally synthesized and externally provided enzymes (as in enzyme replacement therapy) to endosomes is executed by a complex machinery of membrane and… CONTINUE READING