Intracellular trafficking and fate of chimeric adenovirus 5/F35 in human B lymphocytes.

@article{Samson2011IntracellularTA,
  title={Intracellular trafficking and fate of chimeric adenovirus 5/F35 in human B lymphocytes.},
  author={Michel. Samson and Daniel Jung},
  journal={The journal of gene medicine},
  year={2011},
  volume={13 9},
  pages={
          451-61
        }
}
BACKGROUND Investigation of the molecular processes that control the development and function of lymphocytes is essential for our understanding of humoral immunity, as well as lymphocyte-associated pathogenesis. Adenovirus-mediated gene transfer provides a powerful tool for investigating these processes. However, we observed variation in transgene expression among normal human peripheral blood B lymphocytes from different donors and at distinct stages of differentiation. It is recognized that… CONTINUE READING
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