Intracellular topology and epitope shielding of poliovirus 3A protein.

  title={Intracellular topology and epitope shielding of poliovirus 3A protein.},
  author={Sunny S. Choe and Karla Kirkegaard},
  journal={Journal of virology},
  volume={78 11},
The poliovirus RNA replication complex comprises multiple viral and possibly cellular proteins assembled on the cytoplasmic surface of rearranged intracellular membranes. Viral proteins 3A and 3AB perform several functions during the poliovirus replicative cycle, including significant roles in rearranging membranes, anchoring the viral polymerase to these membranes, inhibiting host protein secretion, and possibly providing the 3B protein primer for RNA synthesis. During poliovirus infection… CONTINUE READING

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MHC I-dependent antigen presentation is inhibited by poliovirus protein 3A.

Proceedings of the National Academy of Sciences of the United States of America • 2000

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