Intracellular targeting of truncated secretory peptides in the mammalian heart and brain.

@article{Brun2006IntracellularTO,
  title={Intracellular targeting of truncated secretory peptides in the mammalian heart and brain.},
  author={C{\'e}cile Le Brun and Pierre Philip-Couderc and Mario Raggenbass and Angela Roatti and Alex J. Baertschi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 6},
  pages={
          732-4
        }
}
Secretory polypeptides are vital for nervous system function, sleep, reproduction, growth, and metabolism. Ribosomes scanning the 5'-end of mRNA usually detect the first AUG site for initiating translation. The nascent propeptide chain is then directed via a signal-peptide into the endoplasmic reticulum, processed through the Golgi stacks, and packaged into secretory vesicles. By expressing prepropeptide-EGFP fusion proteins, we observed unusual destinations, mitochondria, nucleus, and… CONTINUE READING