Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.

  title={Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.},
  author={Rachel Linz and Natalie L Barnes and Adriana M. Zimnicka and Jack H Kaplan and Betty A Eipper and Svetlana Lutsenko},
  journal={American journal of physiology. Renal physiology},
  volume={294 1},
Kidneys regulate their copper content more effectively than many other organs in diseases of copper deficiency or excess. We demonstrate that two copper-transporting ATPases, ATP7A and ATP7B, contribute to this regulation. ATP7A is expressed, to a variable degree, throughout the kidney and shows age-dependent intracellular localization. In 2-wk-old mice, ATP7A is located in the vicinity of the basolateral membrane, whereas in 20-wk-old mice, ATP7A is predominantly in intracellular vesicles… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 32 references

Direct visualization of copper-metallothionein in LEC rat kidneys: application of autofluorescence signal of copper-thiolate cluster.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society • 1996
View 3 Excerpts
Highly Influenced

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis

S LaFontaine, Mercer JFB
Arch Biochem Biophys • 2007

Alteration of copper physiology in mice overexpressing the human Menkes protein ATP7A.

American journal of physiology. Regulatory, integrative and comparative physiology • 2006
View 2 Excerpts

Developmental changes in the expression of ATP7A during a critical period in postnatal neurodevelopment

MJ Niciu, XM Ma, +3 authors BA. Eipper
Neuroscience 139: • 2006

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