Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.

@article{Linz2008IntracellularTO,
  title={Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.},
  author={Rachel Linz and Natalie L Barnes and Adriana M. Zimnicka and Jack H Kaplan and Betty A Eipper and Svetlana Lutsenko},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 1},
  pages={F53-61}
}
Kidneys regulate their copper content more effectively than many other organs in diseases of copper deficiency or excess. We demonstrate that two copper-transporting ATPases, ATP7A and ATP7B, contribute to this regulation. ATP7A is expressed, to a variable degree, throughout the kidney and shows age-dependent intracellular localization. In 2-wk-old mice, ATP7A is located in the vicinity of the basolateral membrane, whereas in 20-wk-old mice, ATP7A is predominantly in intracellular vesicles… CONTINUE READING

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