Intracellular study of rat entopeduncular nucleus neurons in an in vitro slice preparation: electrical membrane properties

  title={Intracellular study of rat entopeduncular nucleus neurons in an in vitro slice preparation: electrical membrane properties},
  author={Hidekazu Nakahishi and Hitoshi Kita and Stephen T. Kitai},
  journal={Brain Research},

Electrophysiological properties of cholinergic and noncholinergic neurons in the ventral pallidal region of the nucleus basalis in rat brain slices.

Cholinergic pallidal neurons in brain slices from 6- to 18-day-old rats have similar properties to magnocellular cholinergic neurons in other parts of the forebrain, except that they exhibit strong spike accommodation.

Electrophysiological characterization of entopeduncular nucleus neurons in anesthetized and freely moving rats

The data support the existence of two distinct neuronal populations in the rat EP that can be distinguished by their characteristic firing response to anesthesia, and help reconcile in vitro studies in rats and primates which have reported two distinct populations.

Enhanced Ih depresses rat entopeduncular nucleus neuronal activity from high-frequency stimulation or raised Ke+.

It is shown that the hyperpolarization-activated (I(h) channel mediates the HFS- or K(+)-induced depression of EP neuronal activity and could underlie the inhibitory effects of HFS used in deep brain stimulation in output basal ganglia nuclei.

Cholinergic mechanisms of high-frequency stimulation in entopeduncular nucleus.

This study for the first time describes a cholinergic mechanism of HFS in EP neurons and provides new insight into the underlying mechanisms of DBS, suggesting that muscarinic receptor activation during HFS can lead to feedforward excitation through the opening of CAN channels.



Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.

The electrical activity of Purkinje cells was studied in guinea‐pig cerebellar slices in vitro and antidromic, synaptic and direct electroresponsiveness was demonstrated, indicating Ca spiking and Ca‐dependent K conductance changes are the main events underlying this oscillatory behaviour.

Voltage clamp discloses slow inward current in hippocampal burst-firing neurones

A slow inward current is reported in CA3 neurones of the hippocampus and it is suggested that it is carried by calcium ions, which is similar to that in molluscan and spinal systems.

Analysis of intracellularly recorded phasic bursting by mammalian neuroendocrine cells.

The dependence of the burst characteristics on membrane potential, the apparent lack of patterned synaptic input in most cells, and the ability to evoke bursts with brief stimuli support the hypothesis that bursting in some MNCs involves an endogenous mechanism.

Extracellular activation and membrane conductances of neurones in the guinea‐pig deep cerebellar nuclei in vitro.

The responses of cerebellar nuclear cells to extracellular stimulation in a slice preparation were studied and the ionic basis of their electroresponsiveness was investigated with blockers of

Electrophysiological Study of the Neostriatum in Brain Slice Preparation

The slice preparation enables the investigator to manipulate the extracellular milieu in a controlled manner and is well suited for studying the action of putative neurotransmitters and other agents on the electrical activities of neurons and characterizing the relationships between these membrane activities and specific electrolytes.

The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.

It is proposed that the autorhythmic electrical properties of central neurons and their connectivity form the basis for an intrinsic functional coordinate system that provides internal context to sensory input.

Ionic basis of the differential neuronal activity of guinea‐pig septal nucleus studied in vitro.

The results suggest the existence in intermediate septal neurons of a low‐threshold Ca2+ conductance inactivated at the resting potential and deinactivated by hyperpolarization.

Properties of a persistent inward current in normal and TEA-injected motoneurons.

Membrane currents of normal and TEA-injected cat lumbar motoneurons were investigated using the technique of somatic voltage clamp to suggest that Ii is generated predominantly in a local region under voltage control and that the observed membrane currents govern somatic membrane potential and cell behavior.