Intracellular spermine prevents acid-induced uncoupling of Cx43 gap junction channels

@inproceedings{Skatchkov2015IntracellularSP,
  title={Intracellular spermine prevents acid-induced uncoupling of Cx43 gap junction channels},
  author={Serguei N Skatchkov and Feliksas F. Bukauskas and Jan Benedikt and Mikhail Y Inyushin and Yuriy V. Kucheryavykh},
  booktitle={Neuroreport},
  year={2015}
}
Polyamines (PAs), such as spermine and spermidine, modulate the activity of numerous receptors and channels in the central nervous system (CNS) and are stored in glial cells; however, little attention has been paid to their role in the regulation of connexin (Cx)-based gap junction channels. We have previously shown that PAs facilitate diffusion of Lucifer Yellow through astrocytic gap junctions in acute brain slices; therefore, we hypothesized that spermine can regulate Cx43-mediated (as the… CONTINUE READING

2 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
Polyamines ( PAs ) , such as spermine and spermidine , modulate the activity of numerous receptors and channels in the central nervous system ( CNS ) and are stored in glial cells ; however , little attention has been paid to their role in the regulation of connexin ( Cx)-based gap junction channels .
All Topics