Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75

@article{Vijayasaradhi1995IntracellularSA,
  title={Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75},
  author={Setaluri Vijayasaradhi and Yue Xu and Beryl Bouchard and Alan N. Houghton},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={130},
  pages={807 - 820}
}
The structural and functional integrity of cytoplasmic organelles is maintained by intracellular mechanisms that sort and target newly synthesized proteins to their appropriate cellular locations. In melanocytic cells, melanin pigment is synthesized in specialized organelles, melanosomes. A family of melanocyte-specific proteins, known as tyrosinase-related proteins that regulate melanin pigment synthesis, is localized to the melanosomal membrane. The human brown locus protein, tyrosinase… CONTINUE READING

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