Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury.

  title={Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury.},
  author={Ken-ichi Imahashi and Hideo Kusuoka and Katsuji Hashimoto and J. L. Yoshioka and Hiroichiro Yamaguchi and Tsunehiko Nishimura},
  journal={Circulation research},
  volume={84 12},
To elucidate the role of intracellular Na+ kinetics during ischemia and reperfusion in postischemic contractile dysfunction, intracellular Na+ concentration ([Na+]i) was measured in isolated perfused rat hearts using 23Na nuclear magnetic resonance spectroscopy. The extension of the ischemic period from 9 minutes to 15, 21, and 27 minutes (at 37 degrees C) increased [Na+]i at the end of ischemia from 270.0+/-10.4% of preischemic level (mean+/-SE, n=5) to 348.4+/-12.0% (n=5), 491.0+/-34.0% (n=7… CONTINUE READING

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