Intracellular sites of prothyrotropin-releasing hormone processing.

  title={Intracellular sites of prothyrotropin-releasing hormone processing.},
  author={Ignacio Perez de la Cruz and Eduardo A. Nillni},
  journal={The Journal of biological chemistry},
  volume={271 37},
Post-translational processing of proteins plays a key role in regulating their subcellular localization, enzymatic activity, and protein-protein interactions by such diverse mechanisms as phosphorylation, glycosylation, and proteolytic cleavage. The prothyrotropin-releasing hormone (pro-TRH) precursor (26 kDa) undergoes proteolytic cleavage at either of two sites, generating a 15/10-kDa or a 9.5/16.5-kDa N/C-terminal pair of intermediates. Using transfected AtT20 cells encoding a prepro-TRH… CONTINUE READING