Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin alpha4beta1.

@article{ParmoCabaas2007IntracellularSR,
  title={Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin alpha4beta1.},
  author={Marisa Parmo-Caba{\~n}as and David Garc{\'i}a-Bernal and Rosa Garc{\'i}a-Verdugo and Leonor Kremer and Gabriel M{\'a}rquez and Joaqu{\'i}n Teixid{\'o}},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={82 2},
  pages={380-91}
}
The alpha4beta1 integrin is expressed on thymocytes and mediates cell attachment to its ligands CS-1/fibronectin (CS-1/FN) and VCAM-1 in the thymus. The chemokine CCL25 is highly expressed in the thymus, where it binds to its receptor CCR9 on thymocytes promoting migration and activation. We show here that alpha4beta1 and CCR9 are coexpressed mainly on double- and single-positive thymocytes and that CCL25 strongly stimulates CD4(+)CD8(+) and CD4(+)CD8(-) adhesion to CS-1/FN and VCAM-1. CCL25… CONTINUE READING