Intracellular signaling of osteogenic protein-1 through Smad5 activation.

  title={Intracellular signaling of osteogenic protein-1 through Smad5 activation.},
  author={K. Shimoji T. Kurokawa T. Tamaki and Serhiy Souchelnytskyi and Susumu Itoh and Atsuhito Nakao and Kuber T Sampath and Carl-Henrik Heldin and Peter Ten Dijke},
  journal={Journal of cellular physiology},
  volume={177 2},
Smad proteins play pivotal roles in the intracellular signaling of the multifunctional transforming growth factor-beta (TGF-beta) family members downstream of serine/threonine kinase type I and type II receptors. Smad2 and Smad3 are specific mediators of TGF-beta and activin, while Smadl and Smad5 are involved in bone morphogenetic protein-2 (BMP-2) and BMP-4 signaling. Here we report that osteogenic protein-1 (OP-1), also termed BMP-7, binds predominantly to BMPR-IB in the rat osteoprogenitor… CONTINUE READING