Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.

  title={Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.},
  author={Yaron Goldberg and Gerhild Taimor and Hans Michael Piper and Klaus-Dieter Schl{\"u}ter},
  journal={American journal of physiology. Cell physiology},
  volume={275 5},
Signal transduction pathways involved in the hypertrophic effect of neuropeptide Y (NPY) were investigated in adult cardiomyocytes. Reduction of transforming growth factor-β activity in serum-supplemented media abolished the induction of hypertrophic responsiveness to NPY. In responsive cells, NPY (100 nM) increased protein synthesis, determined as incorporation of [14C]phenylalanine, by 35 ± 15% ( P < 0.05, n = 16 cultures). In these cells, NPY activated pertussis toxin (PTx)-sensitive G… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 18 extracted citations

Neuropeptide y: neurotransmitter or trophic factor in the heart?

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society • 2003
View 10 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 40 references

A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding

M. M. Bradford
Anal. Biochem • 1976
View 3 Excerpts
Highly Influenced

Intracellular signaling of a-adrenoceptor mediated hypertrophy (Abstract)

Schlüter, K.-D, M. Schäfer, G. Taimor, H. M. Piper
Pflügers Arch. Europ. J. Physiol. 433, Suppl. 33, • 1997
View 2 Excerpts

Signal transduction in catecholamine-induced hypertrophy of adult cardiomyocytes (Abstract)

H. M. Piper, K.-D. Schlüter
J. Mol. Cell. Cardiol • 1997
View 3 Excerpts

Similar Papers

Loading similar papers…