Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.

@article{Goldberg1998IntracellularSL,
  title={Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.},
  author={Yaron Goldberg and Gerhild Taimor and Hans Michael Piper and Klaus-Dieter Schl{\"u}ter},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 5},
  pages={C1207-C1215}
}
Signal transduction pathways involved in the hypertrophic effect of neuropeptide Y (NPY) were investigated in adult cardiomyocytes. Reduction of transforming growth factor-β activity in serum-supplemented media abolished the induction of hypertrophic responsiveness to NPY. In responsive cells, NPY (100 nM) increased protein synthesis, determined as incorporation of [14C]phenylalanine, by 35 ± 15% ( P < 0.05, n = 16 cultures). In these cells, NPY activated pertussis toxin (PTx)-sensitive G… CONTINUE READING

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