Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells.

@article{Foote1996IntracellularSF,
  title={Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells.},
  author={Linda C. Foote and Thomas J. Schneider and Gavin M. Fischer and James K. T. Wang and Birgitta Rasmussen and Kim A Campbell and David H. Lynch and S-T. Ju and Ann Marshak-Rothstein and Thomas L. Rothstein},
  journal={Journal of immunology},
  year={1996},
  volume={157 5},
  pages={1878-85}
}
CD40 ligand-activated B cells are sensitive targets for CD4+ Th1 effector cells that kill in a Fas-dependent fashion. Susceptibility to apoptosis is counteracted by Ag receptor binding that produces a state of resistance to Fas engagement in otherwise sensitive targets. In the present study, protection from Th1-mediated apoptosis was found to be induced by protein kinase C and calcium signals, which in combination mimicked the level of Fas resistance produced by surface Ig engagement. Signaling… CONTINUE READING