Intracellular signaling by the unfolded protein response.

  title={Intracellular signaling by the unfolded protein response.},
  author={Sebasti{\'a}n Bernales and Feroz R. Papa and Peter J. Walter},
  journal={Annual review of cell and developmental biology},
The unfolded protein response (UPR) is an intracellular signaling pathway that is activated by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). UPR activation triggers an extensive transcriptional response, which adjusts the ER protein folding capacity according to need. As such, the UPR constitutes a paradigm of an intracellular control mechanism that adjusts organelle abundance in response to environmental or developmental clues. The pathway involves activation of ER… CONTINUE READING
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