Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells.

@article{Zanner2002IntracellularST,
  title={Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells.},
  author={Robert Zanner and Gerhard Hapfelmeier and Manfred Gratzl and Christian Prinz},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={282 2},
  pages={
          C374-82
        }
}
Activation of G(q) protein-coupled receptors usually causes a biphasic increase in intracellular calcium concentration ([Ca(2+)](i)) that is crucial for secretion in nonexcitable cells. In gastric enterochromaffin-like (ECL) cells, stimulation with gastrin leads to a prompt biphasic calcium response followed by histamine secretion. This study investigates the underlying signaling events in this neuroendocrine cell type. In ECL cells, RT-PCR suggested the presence of inositol 1,4,5-trisphosphate… CONTINUE READING

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