Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus.

  title={Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus.},
  author={Neil J. Bennett and Omodele Ashiru and Fiona J E Morgan and Yin Wan Pang and Georgina Okecha and Rob A. Eagle and John Trowsdale and J. G. Sissons and Mark R Wills},
  journal={Journal of immunology},
  volume={185 2},
Human CMV (HCMV) encodes multiple genes that control NK cell activation and cytotoxicity. Some of these HCMV-encoded gene products modulate NK cell activity as ligands expressed at the cell surface that engage inhibitory NK cell receptors, whereas others prevent the infected cell from upregulating ligands that bind to activating NK cell receptors. A major activating NKR is the homodimeric NKG2D receptor, which has eight distinct natural ligands in humans. It was shown that HCMV is able to… CONTINUE READING


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