Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage.

@article{Horn1991IntracellularRT,
  title={Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage.},
  author={Friedemann Horn and Louise M. Bilezikjian and Marilyn H. Perrin and Martha M. Bosma and Jolene J. Windle and Korinna Huber and Amy L. Blount and Bertil Hille and Wylie Vale and Pamela L Mellon},
  journal={Molecular endocrinology},
  year={1991},
  volume={5 3},
  pages={347-55}
}
We recently derived a GnRH-responsive pituitary cell line of the gonadotrope lineage (alpha T3-1) by targeted oncogenesis in transgenic mice. Here, we report studies characterizing the GnRH receptors present in these cells and the intracellular responses to GnRH treatment. The receptors in alpha T3-1 cells show specificity for different GnRH analogs, with dissociation constants very similar to those found in normal rat and mouse pituitary. The concentration of receptors is within the range… CONTINUE READING

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