Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.

@article{Zaniboni2003IntracellularPM,
  title={Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.},
  author={Massimiliano Zaniboni and Pawel Swietach and Alessandra Rossini and Taku Yamamoto and Kenneth W. Spitzer and Richard D. Vaughan-Jones},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 3},
  pages={H1236-46}
}
Intracellular pH (pHi) is an important modulator of cardiac function. The spatial regulation of pH within the cytoplasm depends, in part, on intracellular H+ (Hi+) mobility. The apparent diffusion coefficient for Hi+, DHapp, was estimated in single ventricular myocytes isolated from the rat, guinea pig, and rabbit. DHapp was derived by best-fitting predictions of a two-dimensional model of H+ diffusion to the local rise of intracellular [H+], recorded confocally (ratiometric… CONTINUE READING