Intracellular protein topogenesis.

  title={Intracellular protein topogenesis.},
  author={Gunter Blobel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 3},
  • Gunter Blobel
  • Published 1980 in
    Proceedings of the National Academy of Sciences…
Concurrently with or shortly after their synthesis on ribosomes, numerous specific proteins are unidirectionally translocated across or asymmetrically integrated into distinct cellular membranes. Thereafter, subpopulations of these proteins need to be sorted from each other and routed for export or targeted to other intracellular membranes or compartments. It is hypothesized here that the information for these processes, termed "protein topogenesis," is encoded in discrete "topogenic" sequences… CONTINUE READING

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