Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

@article{Jo2005IntracellularPT,
  title={Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis},
  author={Daewoong Jo and Danya Liu and Shan Yao and Robert D. Collins and Jacek Hawiger},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={892-898}
}
Suppressor of cytokine signaling (SOCS) 3 attenuates proinflammatory signaling mediated by the signal transducer and activator of transcription (STAT) family of proteins. But acute inflammation can occur after exposure to pathogen-derived inducers staphylococcal enterotoxin B (SEB) and lipopolysaccharide (LPS), or the lectin concanavalin A (ConA), suggesting that physiologic levels of SOCS3 are insufficient to stem proinflammatory signaling under pathogenic circumstances. To test this… CONTINUE READING