Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei.

@article{Ginger2005IntracellularPO,
  title={Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei.},
  author={Michael L. Ginger and E Solange Ngazoa and Cl{\'a}udio Pereira and Timothy J. Pullen and Mostafa Kabiri and Katja Becker and Keith Gull and Dietmar Steverding},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 12},
  pages={11781-9}
}
Adenylate kinases occur classically as cytoplasmic and mitochondrial enzymes, but the expression of seven adenylate kinases in the flagellated protozoan parasite Trypanosoma brucei (order, Kinetoplastida; family, Trypanosomatidae) easily exceeds the number of isoforms previously observed within a single cell and raises questions as to their location and function. We show that a requirement to target adenylate kinase into glycosomes, which are unique kinetoplastid-specific microbodies of the… CONTINUE READING

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