Intracellular pools of transferrin receptors result from constitutive internalization of unoccupied receptors.

@article{Ajioka1986IntracellularPO,
  title={Intracellular pools of transferrin receptors result from constitutive internalization of unoccupied receptors.},
  author={Richard S. Ajioka and Jerry Kaplan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 17},
  pages={
          6445-9
        }
}
In HeLa cells the majority of transferrin (Tf) receptors are found within the endocytic apparatus, with only 20% of receptors exposed at the cell surface. Receptor distribution is unaltered by the presence or absence of Tf. The mechanism responsible for the cellular distribution of receptors was explored by selectively inactivating receptors within the endocytic apparatus. This was accomplished by employing Tf-horseradish peroxidase conjugates. Peroxidase-catalyzed oxidation of diaminobenzidine… CONTINUE READING

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