Intracellular pool of IL-10 receptors in specific granules of human neutrophils: differential mobilization by proinflammatory mediators.

@article{Elbim2001IntracellularPO,
  title={Intracellular pool of IL-10 receptors in specific granules of human neutrophils: differential mobilization by proinflammatory mediators.},
  author={Carole Elbim and H{\'e}l{\`e}ne Reglier and Mich{\`e}le Fay and Charlotte Delarche and Val{\'e}rie Andrieu and Jamel El Benna and Marie Anne Gougerot-Pocidalo},
  journal={Journal of immunology},
  year={2001},
  volume={166 8},
  pages={5201-7}
}
IL-10 has a wide range of effects tending to control inflammatory responses. We used flow cytometry to study IL-10 binding at the polymorphonuclear neutrophil (PMN) surface and its modulation by various proinflammatory agents. Little IL-10 bound to the surface of resting PMN. However, binding was strongly increased after stimulation with LPS and proinflammatory cytokines such as TNF and GM-CSF. IL-1 and IL-8 did not significantly modify IL-10 binding. Cycloheximide had no effect on TNF-induced… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…