Intracellular pharmacodynamics of antibiotics.

  title={Intracellular pharmacodynamics of antibiotics.},
  author={St{\'e}phane Carryn and Hugues Chanteux and Cristina Seral and Marie-Paule Mingeot-Leclercq and Françoise Van Bambeke and Paul M Tulkens},
  journal={Infectious disease clinics of North America},
  volume={17 3},
This article establishes the pharmacokinetic-pharmacodynamic parameters that are important when considering the intracellular activity of antibiotics. Generally speaking, the main classes of antibiotics seem to share globally the same properties against extracellular and intracellular organisms. The specific cellular pharmacokinetic properties may modulate those parameters so as to let other ones to become critical. Simple rules, such as equating accumulation and activity, are certainly… CONTINUE READING
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