Intracellular pharmacodynamics of antibiotics.

@article{Carryn2003IntracellularPO,
  title={Intracellular pharmacodynamics of antibiotics.},
  author={St{\'e}phane Carryn and Hugues Chanteux and Cristina Seral and Marie-Paule Mingeot-Leclercq and Françoise Van Bambeke and Paul M Tulkens},
  journal={Infectious disease clinics of North America},
  year={2003},
  volume={17 3},
  pages={
          615-34
        }
}
This article establishes the pharmacokinetic-pharmacodynamic parameters that are important when considering the intracellular activity of antibiotics. Generally speaking, the main classes of antibiotics seem to share globally the same properties against extracellular and intracellular organisms. The specific cellular pharmacokinetic properties may modulate those parameters so as to let other ones to become critical. Simple rules, such as equating accumulation and activity, are certainly… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 109 references

The renal handling of polybasic drugs

Naunyn-Schmiedeberg's Archives of Pharmacology • 2004
View 1 Excerpt

Role of nitric oxide synthesis in macrophage antimicrobial activity

CF Nathan, Hibbs JB
Curr Opin Immunol 1991;3:65–70 • 2003
View 1 Excerpt