Intracellular pathways of copper trafficking in yeast and humans.

  title={Intracellular pathways of copper trafficking in yeast and humans.},
  author={Valeria C Culotta and Shin Lin and Peer Schmidt and Leo W. J. Klomp and Ruby Leah B. Casareno and Jonathan D. Gitlin},
  journal={Advances in experimental medicine and biology},
In the bakers yeast S. cerevisiae, there at least four intracellular targets requiring copper ions-1) Ccc2p and Fet3p in the secretory pathway (homologues to Menkes/Wilson proteins and ceruloplasmin); 2) cytochrome oxidase in the mitochondria; 3) copper transcription factors in the nucleus; and 4) Cu/Zn superoxide dismutase (SOD1) in the cytosol. We have discovered a small soluble copper carrier that specifically delivers copper ions to the secretory pathway. This 8.2 kDa factor known as Atx1p… CONTINUE READING


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