Intracellular pathways for contraction in gastroesophageal smooth muscle cells.

@article{Hillemeier1991IntracellularPF,
  title={Intracellular pathways for contraction in gastroesophageal smooth muscle cells.},
  author={Craig Hillemeier and Khalil N. Bitar and Janice M. Marshall and Piero Biancani},
  journal={The American journal of physiology},
  year={1991},
  volume={260 5 Pt 1},
  pages={G770-5}
}
Intracellular pathways utilized for contraction in response to acetylcholine (ACh), inositol 1,4,5-trisphosphate (IP3), and KCl were examined in isolated circular smooth cells from the esophagus, lower esophageal sphincter (LES), and fundus. In physiological nutrient salt solution (PSS) intact muscle cells isolated from these three tissues responded in a similar dose-dependent manner to ACh. In all tissues the contractile response to ACh was maximal at 30 s. Contraction of smooth muscle cells… CONTINUE READING