Intracellular pH shifts in cultured kidney (A6) cells: effects on apical Na+ transport.

  title={Intracellular pH shifts in cultured kidney (A6) cells: effects on apical Na+ transport.},
  author={W Zeiske and Ilse Smets and Marcel Ameloot and Paul Steels and Willy Van Driessche},
  journal={The American journal of physiology},
  volume={277 3 Pt 1},
We report, for the epithelial Na+ channel (ENaC) in A6 cells, the modulation by cell pH (pHc) of the transepithelial Na+ current (INa), the current through the individual Na+ channel (i), the open Na+ channel density (No), and the kinetic parameters of the relationship between I(Na) and the apical Na+ concentration. The i and N) were evaluated from the Lorentzian INa noise induced by the apical Na+ channel blocker 6-chloro-3, 5-diaminopyrazine-2-carboxamide. pHc shifts were induced, under… CONTINUE READING
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