Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices.

@article{Putnam2001IntracellularPR,
  title={Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices.},
  author={Robert W. Putnam},
  journal={Respiration physiology},
  year={2001},
  volume={129 1-2},
  pages={
          37-56
        }
}
The role of changes of intracellular pH (pH(i)) as the proximal signal in central chemosensitive neurons has been studied. pH(i) recovery from acidification is mediated by Na(+)/H(+) exchange in all medullary neurons and pH(i) recovery from alkalinization is mediated by Cl(-)/HCO(3)(-) exchange in most medullary neurons. These exchangers are more sensitive to inhibition by changes in extracellular pH (pH(o)) in neurons from chemosensitive regions compared to those from nonchemosensitive regions… CONTINUE READING
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