Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line.

@article{Wahl2000IntracellularPR,
  title={Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line.},
  author={Miriam L. Wahl and P M Pooler and Per Briand and D B Leeper and Charles S. Owen},
  journal={Journal of cellular physiology},
  year={2000},
  volume={183 3},
  pages={373-80}
}
Tumor cells in vivo often exist in an ischemic microenvironment that would compromise the growth of normal cells. To minimize intracellular acidification under these conditions, these cells are thought to upregulate H(+) transport mechanisms and/or slow the rate at which metabolic processes generate intracellular protons. Proton extrusion has been compared under identical conditions in two closely related human breast cell lines: nonmalignant but immortalized HMT-3522/S1 and malignant HMT-3522… CONTINUE READING
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