Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts.

@article{Ober1987IntracellularPI,
  title={Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts.},
  author={S S Ober and Arthur B. Pardee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 9},
  pages={2766-70}
}
These studies reveal that a series of tumorigenic Chinese hamster embryo fibroblast (CHEF) cell lines maintain an internal pH (pHi) that is 0.12 +/- 0.04 pH unit above that of the nontumorigenic CHEF/18 parental line. This increase of pHi in the tumorigenic CHEF cells is not due to autocrine growth factor production or to the persistent activation of pathways previously shown to modulate Na+/H+-antiporter activity present in the CHEF/18 line. These findings suggest that the defect in pHi… CONTINUE READING