Intracellular pH changes during zona drilling.

  title={Intracellular pH changes during zona drilling.},
  author={Herman T Depypere and Luc Leybaert},
  journal={Fertility and sterility},
  volume={61 2},
OBJECTIVE To investigate whether zona drilling of oocytes, a technique used to locally disrupt the zona pellucida, causes important changes in intracellular pH. DESIGN AND METHODS In a first set of experiments, intracellular pH was measured during zona drilling of mouse oocytes, using pH-sensitive microelectrodes. In a second set of experiments human oocytes that failed to fertilize were used to measure intracellular pH during drilling. In these cells intracellular pH was measured using… CONTINUE READING

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