Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo.

@article{Kimura2011IntracellularOM,
  title={Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo.},
  author={Katsuji Kimura and Akatsuki Kimura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 1},
  pages={137-42}
}
The centrosome is generally maintained at the center of the cell. In animal cells, centrosome centration is powered by the pulling force of microtubules, which is dependent on cytoplasmic dynein. However, it is unclear how dynein brings the centrosome to the cell center, i.e., which structure inside the cell functions as a substrate to anchor dynein. Here, we provide evidence that a population of dynein, which is located on intracellular organelles and is responsible for organelle transport… CONTINUE READING
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