Intracellular nanosphere subunit assembly as revealed by amelogenin molecular cross-linking studies.

@article{Brookes2006IntracellularNS,
  title={Intracellular nanosphere subunit assembly as revealed by amelogenin molecular cross-linking studies.},
  author={Steven Joseph Brookes and Staale Petter Lyngstadaas and Colin Robinson and Roger C. Shore and Jennifer Kirkham},
  journal={European journal of oral sciences},
  year={2006},
  volume={114 Suppl 1},
  pages={280-4; discussion 285-6, 382}
}
Enamel matrix comprises nanospheres predominantly composed of amelogenin. Studies have shown that recombinant amelogenin forms nanospheres similar to those formed in vivo, but it is unclear exactly how nanospheres assemble in vivo. Are amelogenin monomers secreted into the enamel matrix where they then self-assemble to form nanospheres, or does nanosphere assembly actually occur intracellularly? The aim of this study was to attempt to answer this question. Rat enamel organs were treated with… CONTINUE READING

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