Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure.

@article{Rhind2001IntracellularMA,
  title={Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure.},
  author={Shawn G. Rhind and John W. Castellani and Ingrid Karen Maria Brenner and Roy J Shephard and Jiri Zamecnik and Scott Montain and Andrew J. Young and Pang N. Shek},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={281 1},
  pages={
          R66-75
        }
}
  • S. Rhind, J. Castellani, +5 authors P. Shek
  • Published 1 July 2001
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
This study tested the hypothesis that exercise elicits monocytic cytokine expression and that prolonged cold exposure modulates such responses. Nine men (age, 24.6 +/- 3.8 y; VO(2 peak), 56.8 +/- 5.6 ml. kg(-1). min(-1)) completed 7 days of exhausting exercise (aerobic, anaerobic, resistive) and underwent three cold, wet exposures (CW). CW trials comprised </=6 h (six 1-h rest-work cycles) exposure to cold (5 degrees C, 20 km/h wind) and wet (5 cm/h rain) conditions. Blood samples for the… 
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References

SHOWING 1-10 OF 68 REFERENCES
Effect of exhaustive exercise stress on the cytokine response.
TLDR
It is concluded that exercise of the intensity and duration described here causes an activation of the immune system, which is immediately counter-regulated, and most of the observed changes were back to pre-exercise levels, indicating only a short duration for this suppressive counter-regulation.
Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells.
Physical activity induces a subclinical inflammatory response, mediated in part by leukocytes, and manifested by elevated concentrations of circulating proinflammatory cytokines, including…
Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production.
TLDR
Results show that prolonged exercise elicits a selective down regulation of the proinflammatory cytokine production and upregulation of the cytokines IL-1ra and interleukin-6.
Circulating levels of peripheral blood leucocytes and cytokines following competitive cycling.
TLDR
The results suggest that performance of a 6.5 h competitive cycle-race does not induce a Type-1 or Type-2-dominated cytokine response, but one that is typical of a proinflammatory cytokines response.
Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running.
Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
TLDR
Strenuous exercise induces an increase in the pro‐inflammatory cytokines TNFα and IL‐1β and a dramatic increases in the inflammation responsive cytokine IL‐6, which is balanced by the release of cytokine inhibitors (IL‐1ra, sT NF‐r1 and sTNF‐r2) and the anti‐inflammatoryocyte IL‐10.
Stress hormones and the immunological responses to heat and exercise.
This review focuses on the response of "stress" hormones to heat, exercise (single or repeated bouts), and combinations of these stimuli, with particular reference to their impact upon immune…
Immune changes in humans during cold exposure: effects of prior heating and exercise.
TLDR
It is indicated that acute cold exposure has immunostimulating effects and that, with thermal clamping, pretreatment with physical exercise can enhance this response.
Release of cytokines by blood monocytes during strenuous exercise.
TLDR
Correlations were observed between the in vitro release of IL-6 or TNF-alpha and age, VO2max, maximal ventilation and maximal power output of the subjects, and there was no correlation between the release ofIL-6 and TNF -alpha and lung function measured during hypoxemia.
Adaptation related to cytokines in man: effects of regular swimming in ice-cold water.
TLDR
The cytokine response after thermal stress (sauna + swimming in ice-cold water) was investigated in subjectively healthy persons and the results indicate that adaptive mechanisms occur in habitual winter swimmers.
...
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