Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.

  title={Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.},
  author={Jeremy P. E. Spencer and Gunter G. C. Kuhnle and Robert J Williams and Catherine A. Rice-Evans},
  journal={The Biochemical journal},
  volume={372 Pt 1},
Understanding the cellular effects of flavonoid metabolites is important for predicting which dietary flavonoids might be most beneficial in vivo. Here we investigate the bioactivity in dermal fibroblasts of the major reported in vivo metabolites of quercetin, i.e. 3'-O-methyl quercetin, 4'-O-methyl quercetin and quercetin 7-O-beta-D-glucuronide, relative to that of quercetin, in terms of their further metabolism and their resulting cytotoxic and/or cytoprotective effects in the absence and… CONTINUE READING


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