Intracellular mechanisms of antigen cross presentation in dendritic cells.

  title={Intracellular mechanisms of antigen cross presentation in dendritic cells.},
  author={S{\'e}bastian Amigorena and Ariel Savina},
  journal={Current opinion in immunology},
  volume={22 1},
The induction of most CD8+ T cell responses by dendritic cells (DCs) requires the presentation of peptides from internalized antigen by class I MHC molecules. Increasing number of reports have shown that cross presentation is involved in transplant rejection, in immune responses to viral infections, in certain autoimmune diseases and cancer. The precise role of cross presentation in the initiation of immune responses in vivo, however, remains a matter of debate. This ongoing controversy is, at… CONTINUE READING
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