Intracellular localization of type III-delivered Pseudomonas ExoS with endosome vesicles.

@article{Zhang2007IntracellularLO,
  title={Intracellular localization of type III-delivered Pseudomonas ExoS with endosome vesicles.},
  author={Yue Hong Zhang and Qing Deng and Joseph T. Barbieri},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 17},
  pages={13022-32}
}
ExoS (453 amino acids) is a bi-functional type III cytotoxin produced by Pseudomonas aeruginosa. Residues 96-219 include the Rho GTPase-activating protein (RhoGAP) domain, and residues 234-453 include the 14-3-3-dependent ADP-ribosyltransferase domain. Earlier studies also identified an N-terminal domain (termed the membrane localization domain) that comprises residues 51-77 and includes a novel leucine-rich motif that targets ExoS to the perinuclear region of cultured cells. There is limited… CONTINUE READING