Intracellular localization of the BCL-2 family member BOK and functional implications

  title={Intracellular localization of the BCL-2 family member BOK and functional implications},
  author={Nohemy Echeverry and Daniel Bachmann and F Ke and Andreas Strasser and Hans-Uwe Simon and Thomas Kaufmann},
  journal={Cell Death and Differentiation},
The pro-apoptotic BCL-2 family member BOK is widely expressed and resembles the multi-BH domain proteins BAX and BAK based on its amino acid sequence. The genomic region encoding BOK was reported to be frequently deleted in human cancer and it has therefore been hypothesized that BOK functions as a tumor suppressor. However, little is known about the molecular functions of BOK. We show that enforced expression of BOK activates the intrinsic (mitochondrial) apoptotic pathway in BAX/BAK… CONTINUE READING
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