Intracellular localisation and innate immune responses following Francisella noatunensis infection of Atlantic cod (Gadus morhua) macrophages.

@article{Bakkemo2011IntracellularLA,
  title={Intracellular localisation and innate immune responses following Francisella noatunensis infection of Atlantic cod (Gadus morhua) macrophages.},
  author={Kathrine Ryvold Bakkemo and Helene Mikkelsen and Marianne Bordevik and Jacob S Torgersen and Hanne Cecilie Winther-Larsen and Christin Vanberg and Randi Olsen and Lill-Heidi Johansen and Marit Seppola},
  journal={Fish & shellfish immunology},
  year={2011},
  volume={31 6},
  pages={993-1004}
}
The facultative intracellular bacterium Francisella noatunensis causes francisellosis in Atlantic cod (Gadus morhua), but little is known about its survival strategies or how these bacteria evade the host immune response. In this study we show intracellular localisation of F. noatunensis in cod macrophages using indirect immunofluorescence techniques and green fluorescent labelled bacteria. Transmission electron microscopy revealed that F. noatunensis was enclosed by a phagosomal membrane… CONTINUE READING