Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

Abstract

The compensatory proliferation of insulin-producing β cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of β cells to proliferate results in hyperglycemia and insulin dependence in patients. To understand the effect of the interplay between β cell compensation and lipid metabolism upon obesity and peripheral… (More)
DOI: 10.1172/JCI97702

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